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Dec 14, 2021 · These CAR-iNK cells may be cryopreserved and supplied on demand to each patient, significantly decreasing the manufacturing costs. Moreover, NK cells from PB were found more advantageous in terms of safety and cytotoxic potential against tumors ( 62 ).

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Fig. 1: Schematic illustration of a CAR-T or CAR-NK cell therapy, which uses primary immune cells. (1) T or NK cells are isolated from the patient’s or donor’s blood. (2) Subsequently, cells ...

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Although we noted a slight inhibitory impact on natural cytotoxicity in NK cells isolated and expanded from peripheral blood (PB-NK) against K562 cells expressing physiological levels of HLA-E, this effect was completely overridden in iNK cells and did not interfere with NKG2A + CAR-iNK cell recognition of HLA-E expressing CD19 + target cells ...

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