Higuchi connors phase solubility techniques.

Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, …also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane …

T K Higuchi. T K Higuchi. Phase solubility techniques ... Phase solubility techniques. T K Higuchi. 1, A Connors. 1. View details (2 authors) Volume: 4, Pages: 212 - 217. Published: Jan 1 ... Solubility. Phase diagram. Hildebrand solubility parameter. Paper Details. Title. Phase solubility techniques. Published Date. Jan 1, 1965. Volume. 4 ...5. Higuchi T, Connors K. Phase-solubility techniques. Advances in Analytical Chemistry and Instrumentation, 4, 1965, 117-212 6. Renu Chadha, Anupam Saini, Poonam Arora, Somnath Chanda. Co-crystals of efavirenz with selected coformers: preparation and characterization. International Journal of Pharmacy and Pharmaceutical Sciences Vol 4, …The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBCD. Both the pH and the type of buffer used to adjust the medium pH had a very significant effect on drug solubilities and the apparent binding ...

Phase solubility profiles by Higuchi and Connors [45] Source publication. Mini Review on Synthesis and Characterization Methods for Ternary Inclusion Complexes of Cyclodextrins with Drugs....Higuchi T, Connors KA. Adv anal chem instrum. Phase-solubility Techniques. 1965;. 4:117-212. 10. Zingone G, Rubessa F. Preformulation study of the inclusion ...

phase solubility technique in studying the formation of complex salts of triamterene j pharm sci. 1964 nov;53:1325-8. doi: 10.1002/jps.2600531108.Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5.The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...Phase-solubility analysis. Phase-solubility study was carried out according to the method of Higuchi and Connors . Excess amount of repaglinide (approx. 10 mg) was added to 2.5 mL 10 mM phosphate buffer (pH 6 and pH 3.5) containing increasing amounts of Captisol ® (10 −3 –10 −1 M) and shaken at 25 ± 0.5 °C.The apparent stability constant of the KET- BCD complex, assuming 1:1 stoichiometry, were calculated from the slope of the initial straight portion of the phase solubility diagrams as KH = slope/S0(1 - slope) where So is the solubility of the pure drug (Higuchi and Connors, 1965). All the data are the average of three determinations. 2.3.

Indeed, the absorption coefficient of THC in the complex depends on ligand concentration within the solution. Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965).

The solubility diagram is useful for explaining inclusion complexation of poorly soluble compounds with cyclodextrins as a host in water because it gives not only the solubilizing ability of host but also the stability constant of the complexes by analyzing the solubility curves (Higuchi & Connors, 1965).Fig. 2 shows the phase solubility …

Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ...The Higuchi–Connors phase-solubility method8) is very often used to ... The phase-distribution method is a very versatile and fast method and has the advantage, ...HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 °C, respectively First time of novel dyeing test was performed with complex of curcumin, signified its solubility This study provides useful …Phase solubility studies. Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α ...The phase solubility analysis described by Higuchi and Connors is the most widely used method to describe inclusion complexation (Brewster and Loftsson 2007; Challa et al. 2005). The excess insoluble drug is placed in vials with a constant volume of aqueous carrier containing several solutions with high concentrations of CD.This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained …This was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ...

Fig. 3 displays the effects CDs can have on drug solubility and the classification of the profiles (Higuchi and Connors, 1965). A-type phase solubility profiles are acquired when the solubility of the drug increases with increasing CD concentration through formation of water-soluble drug/CD complexes.Abstract The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability.Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ...Phase solubility studies The apparent stability constants (K s ) were calculated according to the equations established by Higuchi and Connors ( Higuchi & Connors, 1965 ). Under the conditions of the phase-solubility studies, an A L -type phase-solubility diagram with a slope less than unity would be observed, meaning that the …In a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the guest...The phase solubility diagram for complex formation between HC and HPβCD is presented in Fig. 1.The plot shows a typical A L-type solubility curve classified by Higuchi and Connors (1965).The solubility of HC (<0.07 mg/ml) increased in a linear fashion as a function of HPβCD concentration.Higuchi T, Connors K (1965) Phase solubility techniques. In: Reilly CN (ed) Advances in analytical chemistry instrumentation. Interscience, New York, NY, pp 117–212. Google Scholar Jozefaciuk G, Muranyi A, Fenyvesi E (2001) Effect of cyclodextrins on surface and pore properties of soil clay minerals. Environ. Sci.

Higuchi T, Connors KA. Adv anal chem instrum. Phase-solubility Techniques. 1965;. 4:117-212. 10. Zingone G, Rubessa F. Preformulation study of the inclusion ...T K Higuchi. T K Higuchi. Phase solubility techniques ... Phase solubility techniques. T K Higuchi. 1, A Connors. 1. View details (2 authors) Volume: 4, Pages: 212 - 217. …

Phase solubility studies [19]. Phase solubility studies were performed according to the method suggest by Higuchi and Connors. An excess amount of ...31 Ağu 2017 ... The phase solubility studies were carried out to study the effect of cyclodextrins according to the method described by Higuchi and Connors. The ...Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH.The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation.The solubility as a function of HPβCD concentration of the charged and …Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility. Aug 8, 2022 · Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ... Phase solubility study. Classification of inclusion complex formation and stability of the inclusion compounds were evaluated by phase solubility study (Higuchi & Connors, 1965). An excess of black pepper oil was added to 10 mL aqueous solutions of HPβCD ranging in concentration from 0 to 10 mmol/L and incubated at 25 and 35 °C for 24 h with ...The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, …Phase solubility study. The stoichiometry and the overall complex formation constant K 3 were measured according to Higuchi and Connors (experiment A). In addition the determination of the single complex formation constants (K 1 and K 2) were measured by a modified phase solubility (experiment B): (A) Experiment with different concentrations of ...24 Tem 2018 ... This phase-solubility technique was first developed by Higuchi and Connors. ... complex formation solubility, spectral and kinetic techniques. J ...Mar 10, 2023 · Phase-solubility profiles and classification of drug/CD complexes according to Higuchi and Connors . Figure 2. In general, one drug molecule (D) forms a complex with one CD molecule in pure water, and, if the complex is water-soluble, an A L -type phase-solubility diagram is observed ( Table 1 ).

Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5.

If inclusion complexation were the only contribution to drug solubility, it would increase linearly with CD concentration (as per the Higuchi–Connors model); this is because inclusion complexation is a 1 : 1 stoichiometric process. However, solubility curves often deviate from this linearity, whose mechanism is yet to be understood.

The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, or other ligand). Apparent association constants (K a ) values were measured at 25°C in pH 7 phosphate buffer using phase solubility analysis.Abstract. This current work has been conducted mainly to increase solubility and drug release properties for high hydrophobic Dentatin (DEN) by incorporation it into …PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.T K Higuchi. T K Higuchi. Phase solubility techniques ... Phase solubility techniques. T K Higuchi. 1, A Connors. 1. View details (2 authors) Volume: 4, Pages: 212 - 217. …According to Higuchi and Connors’ theory, [17] the phase-solubility relationships between PD and β- and γ-CDs are classified as typical A L-type, ... according to the method reported by Higuchi and Connors (1965). ... Phase solubility techniques. Adv. Anal. Chem. Instrum., 4 (1965), pp. 117-212. View in Scopus Google ScholarPHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...

24 Oca 2006 ... reported by Higuchi and Connors.17 Excess drug (25 mg) was added to 15 mL of ... Phase-solubility techniques. In: Reilly CN, ed. Advances in ...For this purpose, the phase solubility of curcumin was assessed using Higuchi and Connors. ... Phase-solubility techniques. Advances in. Analytical Chemistry and Instrumentation, 4 (2), 117–212.Dec 15, 2014 · Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added. Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117-212. Google ScholarInstagram:https://instagram. pat dementri facebookmeasuring volume gizmo answer key pdfabc observationfsu relays live results Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP-␤-CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP-␤-CD ing different concentrations of HP-␤-CD, ranging from 14.3 mM ... common persimmon fruitatsign pokemon The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl)-β-CyD (DIMEB), randomly methylated-β ...Higuchi T, Connors K. Phase-solubility techniques. Adv Anal . Chem Instr 1965;4:117-22. ... Microwave Irradiation Technique, a Green Chemistry Approach for Dissolution Enhancement of Lopinavir. opponents definition 16 Oca 2019 ... bAL: linear phase-solubility diagram and BS: phase-solubility diagram ... (30) Higuchi, T.; Connors, K. A. Phase-solubility techniques. In.Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117–212. [Google Scholar] 26. Doile KM ...Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH.The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation.The solubility as a function of HPβCD concentration of the charged and …